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Synthetic tetracycline-inducible regulatory networks: computer-aided design of dynamic phenotypes.

Authors
  • Sotiropoulos, Vassilios
  • Kaznessis, Yiannis N
Type
Published Article
Journal
BMC Systems Biology
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Jan 01, 2007
Volume
1
Pages
7–7
Identifiers
PMID: 17408514
Source
Medline
License
Unknown

Abstract

The complexity of biomolecular interactions is accurately captured through computer simulations. Computer simulations allow us to look into the molecular level, portray the dynamic behavior of gene regulatory networks and rationally engineer novel ones with useful applications. We are able to propose, test and accept or reject design principles for each network. Guided by simulations, we develop a set of design principles for novel tetracycline-inducible networks.

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