Affordable Access

deepdyve-link
Publisher Website

Synthetic studies toward the mannopeptimycins: synthesis of orthogonally protected beta-hydroxyenduracididines.

Authors
  • Olivier, Kevin S
  • Van Nieuwenhze, Michael S
Type
Published Article
Journal
Organic Letters
Publisher
American Chemical Society
Publication Date
Apr 16, 2010
Volume
12
Issue
8
Pages
1680–1683
Identifiers
DOI: 10.1021/ol100219a
PMID: 20232818
Source
Medline
License
Unknown

Abstract

The asymmetric synthesis of the nonproteinogenic amino acids (2S,3S,4'S)-beta-hydroxyenduracididine 3 and (2R,3S,4'S)-beta-hydroxyenduracididine 4 in orthogonally protected form in 15 total steps from Garner's aldehyde is reported. The former and N-glycosylated form of the latter are found in the glycopeptide antibiotic mannopeptimycin.

Report this publication

Statistics

Seen <100 times