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Synthetic Polypeptide Polymers as Simplified Analogues of Antimicrobial Peptides

Authors
  • Salas-Ambrosio, Pedro
  • Tronnet, Antoine
  • Verhaeghe, Pierre
  • Bonduelle, Colin
Publication Date
Jul 27, 2020
Identifiers
DOI: 10.1021/acs.biomac.0c00797
OAI: oai:HAL:hal-02931945v1
Source
HAL-Descartes
Keywords
Language
English
License
Unknown
External links

Abstract

Antimicrobial peptides (AMPs) are naturally occurring macromolecules made of amino acids that are potent broad-spectrum antibiotics with potential as novel therapeutic agents. This review aims to summarize the fundamental principles concerning the structure and mechanism of action of these AMPs, in order to guide the design of polymeric analogues that organic chemistry can generate. Among those simplified analogues, this review particularly focuses on those made of amino acids called polypeptide polymers: they are showing great potential by providing one of the best biomimetic and bioactive structures for further biomaterials science applications.

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