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Synthetic genomics: a new venture to dissect genome fundamentals and engineer new functions.

Authors
  • Schindler, Daniel1
  • Dai, Junbiao2
  • Cai, Yizhi3
  • 1 Manchester Institute of Biotechnology, University of Manchester, 131 Princess Street, M1 7DN Manchester, UK.
  • 2 Centre for Synthetic Genomics, Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China. , (China)
  • 3 Manchester Institute of Biotechnology, University of Manchester, 131 Princess Street, M1 7DN Manchester, UK; Centre for Synthetic Genomics, Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China. Electronic address: [email protected] , (China)
Type
Published Article
Journal
Current opinion in chemical biology
Publication Date
Oct 01, 2018
Volume
46
Pages
56–62
Identifiers
DOI: 10.1016/j.cbpa.2018.04.002
PMID: 29751161
Source
Medline
Language
English
License
Unknown

Abstract

Since the first synthetic gene was synthesized in 1970s, the efficiency and the capacity of made-to-order DNA sequence synthesis has increased by several orders of magnitude. Advances in DNA synthesis and assembly over the past years has resulted in a steep drop in price for custom made DNA. Similar effects were observed in DNA sequencing technologies which underpin DNA-reading projects. Today, synthetic DNA sequences with more than 10000bps and turn-around times of a few weeks are commercially available. This enables researchers to perform large-scale projects to write synthetic chromosomes and characterize their functionalities in vivo. Synthetic genomics opens up new paradigms to study the genome fundamentals and engineer novel biological functions. Copyright © 2018 Elsevier Ltd. All rights reserved.

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