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Synthetic Biology Approaches to Engineer Probiotics and Members of the Human Microbiota for Biomedical Applications

Authors
  • Bober, Josef R.
  • Beisel, Chase L.
  • Nair, Nikhil U.
Type
Published Article
Journal
Annual Review of Biomedical Engineering
Publisher
Annual Reviews
Publication Date
Jun 04, 2018
Volume
20
Pages
277–300
Identifiers
DOI: 10.1146/annurev-bioeng-062117-121019
Source
Annual Reviews
Keywords
License
Yellow

Abstract

An increasing number of studies have strongly correlated the composition of the human microbiota with many human health conditions and, in several cases, have shown that manipulating the microbiota directly affects health. These insights have generated significant interest in engineering indigenous microbiota community members and nonresident probiotic bacteria as biotic diagnostics and therapeutics that can probe and improve human health. In this review, we discuss recent advances in synthetic biology to engineer commensal and probiotic lactic acid bacteria, bifidobacteria, and Bacteroides for these purposes, and we provide our perspective on the future potential of these technologies.

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