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Synthesis and in vitro cytotoxicity of novel long chain busulphan analogues.

Authors
  • Kokotos, G
  • Constantinou-Kokotou, V
  • Padrón, J M
  • Peters, G J
Type
Published Article
Journal
Bioorganic & Medicinal Chemistry Letters
Publisher
Elsevier
Publication Date
Mar 26, 2001
Volume
11
Issue
6
Pages
861–863
Identifiers
PMID: 11277538
Source
Medline
License
Unknown

Abstract

Two novel long chain alkanediol dimethanesulphonates, analogues of busulphan, were synthesized. Their in vitro cytotoxicity was evaluated against six solid tumor cell lines (A2780, H322, LL, WiDr, C26-10 and UMSCC-22B). 2-Tetradecylbutane-1,4-diol dimethanesulphonate was proved to be the most active compound exhibiting IC50 values between 20.82 and 26.36 microM.

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