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Synthesis and In vitro cytotoxicity of cinnamaldehydes to human solid tumor cells

Authors
  • kwon, byoung-mog
  • lee, seung
  • choi, sang
  • park, sung hee
  • lee, chong ock
  • cho, young kwon
  • sung, nack
  • bok, song hae
Publication Date
Jan 01, 1998
Source
KRIBB Repository
Keywords
License
Unknown
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Abstract

Cinnamaldehydes and related compounds were synthesized from various cinnamic acids based on the 2′-hydroxycinnamaldehyde isolated from the bark of Cinnamomum cassia Blume. The cytotoxicity to human solid tumor cells such as A549, SK-OV-3, SK-MEL-2, XF498 and HCT15 were measured. Cinnamic acid, cinnamates and cinnamyl alcohols did not show any cytotoxicity against the human tumor cells. Cinnamaldehydes and realted compounds were resistant to A549 cell line up to 15 μg/ml. In contrast, HCT15 and SK-MEL-2 cells were much sensitive to these cinnamaldehyde analogues which showed ED50 values 0.63∼8.1 μg/ml. Cytotoxicity of the saturated aldehydes was much weak compared to their unsaturated aldehydes. From these studies, it was found that the key functional group of the cinnamaldehyde-related compounds in the antitumor activity is the propenal group. / open

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