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Synthesis of two 3,5-disubstituted sulfonamide catechol ligands and evaluation of their iron(III) complexes for use as MRI contrast agents.

Authors
  • Schwert, Daniel D
  • Richardson, Nicholas
  • Ji, Gongjun
  • Radüchel, Bernd
  • Ebert, Wolfgang
  • Heffner, Peter E
  • Keck, Rick
  • Davies, Julian A
Type
Published Article
Journal
Journal of medicinal chemistry
Publication Date
Nov 17, 2005
Volume
48
Issue
23
Pages
7482–7485
Identifiers
PMID: 16279808
Source
Medline
License
Unknown

Abstract

Two 3,5-disubstituted sulfonamide catechol ligands were synthesized. Tris(ligand) iron(III) complexes were prepared and investigated as MRI contrast agents. Longitudinal relaxivity (r1) values were determined for the complexes. The r1 values in water were substantially higher than those of typical six-coordinate iron(III) complexes. The r1 values in plasma under the same conditions increased. The iron(III) complexes were administered to rats, and the kidney and liver signal intensities were measured by T1-weighted MR imaging experiments.

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