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Synthesis and structure--activity relationship of nonyl 3-acyldithiocarbazates and related compounds for uncoupling activities.

Authors
  • Uda, M
  • Toyooka, K
  • Horie, K
  • Shibuya, M
  • Kubota, S
  • Terada, H
Type
Published Article
Journal
Journal of medicinal chemistry
Publication Date
May 01, 1982
Volume
25
Issue
5
Pages
557–560
Identifiers
PMID: 7086842
Source
Medline
License
Unknown

Abstract

Various nonyl 3-substituted-dithiocarbazates, methyl and dimethyl derivatives of nonyl 3-benzoyldithiocarbazate, nonyl 2-substituted-dithiocarbamates, and benzaldehyde nonyldithiocarbohydrazone were synthesized and their uncoupling activities of oxidative phosphorylation in mitochondria were examined. The results indicate that the presence of the thiocarbamoyl structure with the potential SH group is a requisite for uncoupling activity. The presence of a C=O group and a hydrophobic aromatic ring significantly increases the uncoupling activity.

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