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"Synthesis, structural characterization and in vitro anti-cancer activity of functionalized N-heterocyclic carbene platinum and palladium complexes "

Authors
  • "Georges Dahm,
  • Corinne Bailly,
  • Lydia Karmazin,
  • Stéphane Bellemin-Laponnaz",
  • Georges Dahm
Type
Published Article
Journal
Journal of Organometallic Chemistry
Publisher
Elsevier
Publication Date
Jan 01, 0000
Source
MyScienceWork
License
Unknown

Abstract

"Abstract A series of platinum(II) and palladium(II) complexes bearing N-heterocyclic carbene ligands functionalized by specific functionalities such as alcohol, nitrile or ester were synthesized. The novel complexes were fully characterized and X-ray diffraction was used for the structure determination of eight derivatives. The reactivity of the functional groups has been studied; for example, Pt and Pd \NHC\ complexes containing tBu ester functions were easily hydrolyzed giving water-soluble \NHC\ complexes. The palladium complex 21 containing dangling \COOH\ group was evaluated in copper-free Sonogashira coupling reaction. In addition, platinum \NHC\ complexes are attractive metal-based systems for the development of anticancer drugs. Preliminary results of the biological effects on various human cancer and non-cancer cells are also reported. "

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