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Synthesis of some new azoles and azines and their condensed derivatives.

Authors
  • Ahmed, Gamal A
Type
Published Article
Journal
Bollettino chimico farmaceutico
Publication Date
Jan 01, 2002
Volume
141
Issue
6
Pages
438–442
Identifiers
PMID: 12577513
Source
Medline
License
Unknown

Abstract

Ethyl (2,5-Dimethylphenyl) pyruvate (2) condensed with o-phenylenediamine, ethylenediamine, semicarbazide and thiosemicarbazide and gave quinoxaline derivative (3), dihydropyrazine derivative (9) and 1,2,4-triazine derivatives (10, 11) respectively. Compound (3) reacted with phosphorous pentasulphide, polyphosphoric acid, semicarbazide hydrochloride and phenylisothiocyanate yielded thienoquinoxaline derivative (4), furoquinoxaline derivative (5), semicarbazone derivative (6) and pyrrole derivative (15) respectively. Reaction of (2) with hydrazines and malononitrile afforded the arylpyrazole derivatives (12a, b) and pyrane derivative (13) respectively. Heterocyclization of compound (6) afforded thiadiazole and selenodiazole derivatives (7), (8).

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