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Synthesis of short-chain hydroxyaldehydes and their 2,4-dinitrophenylhydrazone derivatives, and separation of their isomers by high-performance liquid chromatography.

Authors
  • Frey, Jasmin1
  • Schneider, Fabian2
  • Schink, Bernhard3
  • Huhn, Thomas2
  • 1 Department of Biology, University of Konstanz, D-78457 Konstanz, Germany. Electronic address: [email protected] , (Germany)
  • 2 Department of Chemistry, University of Konstanz, D-78457 Konstanz, Germany. , (Germany)
  • 3 Department of Biology, University of Konstanz, D-78457 Konstanz, Germany. , (Germany)
Type
Published Article
Journal
Journal of chromatography. A
Publication Date
Jan 05, 2018
Volume
1531
Pages
143–150
Identifiers
DOI: 10.1016/j.chroma.2017.11.046
PMID: 29174570
Source
Medline
Keywords
License
Unknown

Abstract

An easy to handle high-performance liquid chromatography (HPLC) method for the separation of structural isomers of short-chain aldehydes as their hydrazones is presented. Some aldehydes were not available as reference compounds, therefore, synthesis routes for these hydroxy-aldehydes and their dinitrophenylhydrazone derivatives are reported. The reported method has a detection limit of 2.4-16.1μg/L for the hydrazones and shows good linearity and reproducibility for various tested aldehydes.

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