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Synthesis of Selenium Nanoparticles Stabilized with Sodium Carboxymethylcellulose for Preparation of a Long-Acting Form of Prospidine

Authors
  • Yunusov, Kh. E.1
  • Sarymsakov, A. A.1
  • Turakulov, F. M.1
  • Rashidova, S. Sh.1
  • Yurkshtovich, T. L.2
  • Kokhan, A. V.2
  • Yurkshtovich, N. K.2
  • Alinovskaya, V. A.2
  • Bychkovskii, P. M.3
  • Golub, N. V.2
  • Solomevich, S. O.2
  • 1 Institute of Polymer Chemistry and Physics, Academy of Sciences of the Republic Uzbekistan, Tashkent, 700128, Uzbekistan , Tashkent (Uzbekistan)
  • 2 Research Institute of Physicochemical Problems, Belarusian State University, Minsk, 220030, Belarus , Minsk (Belarus)
  • 3 Educational Scientific Production Republican Unitary Enterprise “Unitechprom BSU”, Minsk, 220045, Belarus , Minsk (Belarus)
Type
Published Article
Journal
Russian Journal of Applied Chemistry
Publisher
Pleiades Publishing
Publication Date
Sep 01, 2021
Volume
94
Issue
9
Pages
1259–1266
Identifiers
DOI: 10.1134/S1070427221090081
Source
Springer Nature
Keywords
Disciplines
  • Macromolecular Compounds and Polymeric Materials
License
Yellow

Abstract

AbstractStable selenium nanoparticles were synthesized in a sodium carboxymethylcellulose (Na-CMC) solution with a degree of substitution of 0.85 and an average molar weight of 250 000. The shape and size of selenium nanoparticles were determined by dynamic light scattering and UV spectroscopy. It was found that the nanoparticles coated with Na-CMC are stable upon storage for 28 days. A significant prolongation of the release of the prospidine antitumor agent from stabilized nanoparticles has been shown. Broad spectrum drugs, in particular, anticancer drugs and drugs that compensate for selenium deficiency in the body can be produced based on the selenium nanoparticles coated with Na-CMC.

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