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Synthesis of S-adenosyl-L-homocysteine hydrolase inhibitors and their biological activities.

Authors
  • Kitade, Y
  • Kozaki, A
  • Gotoh, T
  • Miwa, T
  • Nakanishi, M
  • Yatome, C
Type
Published Article
Journal
Nucleic acids symposium series
Publication Date
Jan 01, 1999
Issue
42
Pages
25–26
Identifiers
PMID: 10780361
Source
Medline
License
Unknown

Abstract

Several nucleosides have been prepared as a possible inhibitor of human S-adenosyl-L-homocysteine (SAH) hydrolase for the development of anti-viral agents. Recently, SAH hydrolase has been considered as an attractive target for parasite chemotherapy for malaria. We report synthesis of several nucleosides including carbocyclic nucleosides and their inhibitory activities against recombinant malaria and human SAH hydrolases.

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