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Synthesis of porous PEG microgels using CaCO3 microspheres as hard templates.

Authors
  • Behra, Muriel1
  • Schmidt, Stephan
  • Hartmann, Jürgen
  • Volodkin, Dmitry V
  • Hartmann, Laura
  • 1 Max Planck Institute of Colloids and Interfaces, Am Mühlenberg 1, 14476 Potsdam-Golm, Germany. , (Germany)
Type
Published Article
Journal
Macromolecular rapid communications
Publication Date
Jun 27, 2012
Volume
33
Issue
12
Pages
1049–1054
Identifiers
DOI: 10.1002/marc.201100863
PMID: 22392732
Source
Medline
License
Unknown

Abstract

Porous poly(ethylene glycol) (PEG) microgels of both 17.6 and 8.3 μm in diameter are synthesized via hard templating with calcium carbonate (CaCO(3)) microparticles. The synthesis is performed in three steps: loading of PEG macromonomers into CaCO(3) microparticles, crosslinking via photopolymerization, and removal of the CaCO(3) template under acidic conditions. The resulting porous PEG microgels are inverse replicates of their templates as indicated by light microscopy, cryo-scanning electron microscopy (cryo-SEM), and permeability studies. Thus this process allows for the straightforward and highly reproducible synthesis of porous hydrogel particles of two different diameters and porosities that show great potential as carriers for drugs or nanomaterials.

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