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Synthesis of phosphorylated recognition marker in lysosomal enzymes is located in the cis part of Golgi apparatus.

Authors
  • Pohlmann, R
  • Waheed, A
  • Hasilik, A
  • von Figura, K
Type
Published Article
Journal
Journal of Biological Chemistry
Publisher
American Society for Biochemistry & Molecular Biology (ASBMB)
Publication Date
May 25, 1982
Volume
257
Issue
10
Pages
5323–5325
Identifiers
PMID: 6279593
Source
Medline
License
Unknown

Abstract

Rat liver membranes were subjected to centrifugation in a sucrose density gradient in which the Golgi apparatus was separated into several subfractions. Two enzymes involved in the synthesis of the phosphorylated recognition marker in lysosomal enzymes, UDP-N-acetylglucosamine:lysosomal enzyme precursor N-acetylglucosamine-1-phosphotransferase and alpha-N-acetylglucosaminyl phosphodiesterase fractionated with alpha-1,2-mannosidase, a marker enzyme of cis Golgi membranes and differently from galactosyltransferase, a marker enzyme of trans Golgi membranes.

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