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Synthesis and pharmacological evaluation of new flosulide analogues, synthesized from natural safrole.

Authors
  • Lages, A S
  • Silva, K C
  • Miranda, A L
  • Fraga, C A
  • Barreiro, E J
Type
Published Article
Journal
Bioorganic & Medicinal Chemistry Letters
Publisher
Elsevier
Publication Date
Jan 20, 1998
Volume
8
Issue
2
Pages
183–188
Identifiers
PMID: 9871651
Source
Medline
License
Unknown

Abstract

Four new aryl-sulfonamide derivatives (3a, 4a, 5a-b), having methylenedioxy group attached to phenyl ring, were prepared from natural safrole and evaluated as anti-inflammatory agents. The N-methylsulfonamide 3a and corresponding retrosulfonamide derivative 5a were more active than standards indomethacin and nimesulide, at the same molar concentration, in carrageenan-induced pleurisy assay.

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