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Synthesis of novel nucleotide analogues possessing a difluoromethylenephosphonato group. Evaluation of the inhibitory activity for purine nucleoside phosphorylase.

Authors
  • Yokomatsu, T
  • Hayakawa, Y
  • Abe, H
  • Shibuya, S
  • Kihara, T
  • Soeda, S
  • Shimeno, H
Type
Published Article
Journal
Nucleic acids symposium series
Publication Date
Jan 01, 1999
Issue
42
Pages
27–28
Identifiers
PMID: 10780362
Source
Medline
License
Unknown

Abstract

Novel nucleotide analogues 1-6 were prepared as "multi-substrate" analogue inhibitors for purine nucleoside phosphorylases (PNPs). The cyclopropane and the tetrahydrofuran moieties of the alkyl spacer connecting a nucleobase and difluoromethylene phosphonic acid were found to be effective for good inhibition of PNPs.

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