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Synthesis of novel 3'-deoxy-3'-C-hydroxymethyl nucleosides with conformationally rigid sugar moiety as potential antiviral agents.

Authors
  • Chun, M W
  • Kim, M J
  • Jo, U H
  • Kim, J H
  • Kim, H D
  • Jeong, L S
Type
Published Article
Journal
Nucleosides, nucleotides & nucleic acids
Publication Date
Jan 01, 2001
Volume
20
Issue
4-7
Pages
699–702
Identifiers
PMID: 11563095
Source
Medline
License
Unknown

Abstract

Based on the fact that the ring expanded 3'-C-hydroxymethyl analogue of oxetanocin A exhibited potent antiviral activity, two types of conformationally rigid 3'-C-hydroxymethyl derivatives in which 2'-hydroxyl group is linked to the 4'-position or to the 6'-position were synthesized starting from 1,2;5,6-di-O-isopropylidene-D-glucose, respectively.

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