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Synthesis of new ibuprofen hybrid conjugates as potential anti-inflammatory and analgesic agents.

Authors
  • Panda, Siva S1
  • Girgis, Adel S2
  • Honkanadavar, Hitesh H1
  • George, Riham F3
  • Srour, Aladdin M4
  • 1 Department of Chemistry & Physics, Augusta University, Augusta, GA 30912, USA.
  • 2 Department of Pesticide Chemistry, National Research Centre, Dokki, Giza, 12622, Egypt. , (Egypt)
  • 3 Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt. , (Egypt)
  • 4 Department of Therapeutic Chemistry, National Research Centre, Dokki, Giza, 12622, Egypt. , (Egypt)
Type
Published Article
Journal
Future Medicinal Chemistry
Publisher
"Future Science, LTD"
Publication Date
Aug 01, 2020
Volume
12
Issue
15
Pages
1369–1386
Identifiers
DOI: 10.4155/fmc-2020-0109
PMID: 32689823
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Background: A new set of hybrid conjugates derived from 2-(4-isobutylphenyl)propanoic acid (ibuprofen) is synthesized to overcome the drawbacks of the current non-steroidal anti-inflammatory drugs. Results & methodology: Synthesized conjugates were screened for their anti-inflammatory, analgesic and ulcerogenic properties. Few conjugates were found to have significant anti-inflammatory properties in the carrageenan-induced rat paw edema test, while a fair number of conjugates showed promising peripheral analgesic activity in the acetic acid-induced writhing test as well as central analgesic properties in the in vivo hot plate technique. The newly synthesized conjugates did not display any ulcerogenic liability. Conclusion: In vitro, COX-1 and COX-2 enzyme inhibition studies raveled compound 7e is more selective toward COX-2 compared with ibuprofen.

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