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Synthesis of a new class of HIV-1 inhibitors.

Authors
  • Farese-Di Giorgio, A
  • Pairot, S
  • Patino, N
  • Condom, R
  • Di Giorgio, C
  • Aumelas, A
  • Aubertin, A M
  • Guedj, R
Type
Published Article
Journal
Nucleosides & nucleotides
Publication Date
Feb 01, 1999
Volume
18
Issue
2
Pages
263–275
Identifiers
PMID: 10067276
Source
Medline
License
Unknown

Abstract

A new family of molecules potentially inhibitors of the HIV-1 Tat-TAR complex was prepared. These compounds are constituted by dinucleotide analogs (PNA dimer) bound, through a linker, to an arginine residue. In this series, several molecules inhibit viral development in cell culture with a micromolar IC50 and without cellular toxicity until 200 microM concentration.

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