Synthesis of n-heteroaryl-7-azabicyclo[2.2.1]heptane derivatives via palladium-bisimidazol-2-ylidene complex catalyzed amination reactions.
Department of Chemistry, University of New Orleans, New Orleans, Louisiana 70148, USA.
- Published Article
American Chemical Society
- Publication Date
May 03, 2001
[reaction in text] A one-step approach to novel N-heteroaryl-substituted-7-azabicyclo[2.2.1]heptanes from readily available heteroaryl halides and 7-azabicyclo[2.2.1]heptane has been achieved. The cross-coupling amination reaction employs palladium-bisimidazol-2-ylidene complexes as catalysts to give good to moderate yields over a wide variety of substrates.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/11348237