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Synthesis of n-heteroaryl-7-azabicyclo[2.2.1]heptane derivatives via palladium-bisimidazol-2-ylidene complex catalyzed amination reactions.

Authors
  • 1
Type
Published Article
Journal
Organic Letters
1523-7060
Publisher
American Chemical Society
Publication Date
Volume
3
Issue
9
Pages
1371–1374
Identifiers
PMID: 11348237
Source
Medline

Abstract

[reaction in text] A one-step approach to novel N-heteroaryl-substituted-7-azabicyclo[2.2.1]heptanes from readily available heteroaryl halides and 7-azabicyclo[2.2.1]heptane has been achieved. The cross-coupling amination reaction employs palladium-bisimidazol-2-ylidene complexes as catalysts to give good to moderate yields over a wide variety of substrates.

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