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Synthesis of a monophosphoryl lipid A derivative and its conjugation to a modified form of a tumor-associated carbohydrate antigen GM3.

Authors
  • Wang, Qianli
  • Xue, Jie
  • Guo, Zhongwu
Type
Published Article
Journal
Chemical Communications
Publisher
The Royal Society of Chemistry
Publication Date
Oct 07, 2009
Issue
37
Pages
5536–5537
Identifiers
DOI: 10.1039/b907351e
PMID: 19753348
Source
Medline
License
Unknown

Abstract

An efficient synthesis of a derivative of monophosphoryl lipid A suitable for coupling to various structures for the construction of glycoconjugate vaccines and its conjugation with an N-modified form of the tumor-associated antigen GM3 is presented.

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