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Synthesis, molecular docking and evaluation of 3-{4-[2-amino-4-(substitutedphenyl)-2H-[1, 3] oxazin/thiazin-6-yl} 2-phenyl-3H-quinazolin-4-one derivatives for their anticonvulsant activity.

Authors
  • Jain, Nimisha
  • Jaiswal, Jugnu
  • Pathak, Ashish
  • Singour, Pradeep Kumar1
  • 1 VNS Group of Institutions-Faculty of Pharmacy, India.
Type
Published Article
Journal
Central nervous system agents in medicinal chemistry
Publication Date
Jan 04, 2017
Identifiers
PMID: 28056730
Source
Medline
License
Unknown

Abstract

All the newly synthesized compounds had significant anticonvulsant activity. The same two compounds 5a and 5d showed promising activity, while the other compounds have moderate activity. The proposed work is to effort towards the development and identification of novel molecules as anticonvulsant agents by synthesis of some novel quinazolinone derivatives with improved biological activity.

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