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[Synthesis of lipid A analogs. Preparation of serologically active glycolipids on the basis of beta-1,4-glucosaminobiose (chitobiose)].

Authors
  • Gorbach, V I
  • Luk'ianov, P A
  • Krasikova, I N
  • Solov'eva, T F
  • Ovodov, Iu S
Type
Published Article
Journal
Bioorganicheskaia khimiia
Publication Date
Oct 01, 1987
Volume
13
Issue
10
Pages
1409–1415
Identifiers
PMID: 2449221
Source
Medline
License
Unknown

Abstract

Synthesis of beta-1,4-glucosaminobiose (chitobiose) 4'-phosphates N,N'-diacylated with (R)-3-hydroxymyristic acid is described, the structure being corroborated by 13C-NMR spectra. It was shown that activity of the components in various reactions with antibodies to lipid A from Yersinia pseudotuberculosis is similar to the lipid A activity.

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