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Synthesis of iridium-based nanocomposite with catalase activity for cancer phototherapy

Authors
  • Wu, Hang1
  • Jiang, Qi2
  • Luo, Keyi3
  • Zhu, Chunping2
  • Xie, Mengmeng3
  • Wang, Shige3
  • Fei, Zhewei1
  • Zhao, Jiulong2
  • 1 Shanghai Jiaotong University School of Medicine, No. 1665 Kongjiang Road, Shanghai, 200433, People’s Republic of China , Shanghai (China)
  • 2 Second Military Medical University, No. 168 Changhai Road, Shanghai, 200433, People’s Republic of China , Shanghai (China)
  • 3 University of Shanghai for Science and Technology, No. 334 Jungong Road, Shanghai, 200093, People’s Republic of China , Shanghai (China)
Type
Published Article
Journal
Journal of Nanobiotechnology
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Jul 07, 2021
Volume
19
Issue
1
Identifiers
DOI: 10.1186/s12951-021-00948-8
Source
Springer Nature
Keywords
Disciplines
  • Research
License
Green

Abstract

The combination of photothermal therapy (PTT) and photodynamic therapy (PDT) has attracted attention due to its enhanced tumor therapy effect. This study proposes a novel nanoenzyme-based theranostic nanoplatform, [email protected]@PDA-BSA(Ce6), for the combined PTT and PDT of tumors. IrO2 was prepared by a simple hydrolysis method and coated with a thin layer of mesoporous silica (MSN) to facilitate the physical adsorption of Chlorin e6 (Ce6). The PDA coating and IrO2 NPs of the nanoplatform demonstrated an improved photothermal conversion efficiency of 29.8% under NIR irradiation. Further, the Ce6 loading imparts materials with the ability to produce reactive oxygen species (ROS) under 660 nm NIR laser irradiation. It was also proved that the IrO2 NPs could catalyze the hydrogen peroxide (H2O2) in the tumor microenvironment (TME) to generate endogenous oxygen (O2), thereby enhancing the efficiency of PDT. The in vitro and in vivo experiments indicated that the nanocomposite was highly biocompatible and could produce a satisfactory tumor therapeutic effect. Thus, the findings of the present study demonstrate the viability of using theranostic nanoenzymes for translational medicine.

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