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Synthesis and immunosuppressive activity of ruthenium complexes.

Authors
  • Bastos, C M
  • Gordon, K A
  • Ocain, T D
Type
Published Article
Journal
Bioorganic & Medicinal Chemistry Letters
Publisher
Elsevier
Publication Date
Jan 20, 1998
Volume
8
Issue
2
Pages
147–150
Identifiers
PMID: 9871643
Source
Medline
License
Unknown

Abstract

The syntheses and immunosuppressive activity of ruthenium complexes are described. One of the complexes (1a) was shown to be a potent inhibitor of human T-lymphocyte proliferation with an IC50 of 5 nM. The activity of these complexes compares favorably to the well known immunosuppressants Cyclosporin A and Rapamycin.

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