Synthesis and immunosuppressive activity of ruthenium complexes.
- Authors
- Type
- Published Article
- Journal
- Bioorganic & Medicinal Chemistry Letters
- Publisher
- Elsevier
- Publication Date
- Jan 20, 1998
- Volume
- 8
- Issue
- 2
- Pages
- 147–150
- Identifiers
- PMID: 9871643
- Source
- Medline
- License
- Unknown
Abstract
The syntheses and immunosuppressive activity of ruthenium complexes are described. One of the complexes (1a) was shown to be a potent inhibitor of human T-lymphocyte proliferation with an IC50 of 5 nM. The activity of these complexes compares favorably to the well known immunosuppressants Cyclosporin A and Rapamycin.
