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Synthesis and immobilization of ceramide analogs on silica particles.

Authors
  • Yin, J
  • Liu, H
  • Pidgeon, C
Type
Published Article
Journal
Bioorganic & Medicinal Chemistry Letters
Publisher
Elsevier
Publication Date
Jan 20, 1998
Volume
8
Issue
2
Pages
179–182
Identifiers
PMID: 9871650
Source
Medline
License
Unknown

Abstract

Ceramides are the major lipid components of the stratum corneum, the major permeability barrier of the skin. Here we report a chemical synthesis of ceramide analogs covalently bonded on the silica particles, that can be used to predict the skin permeability of chemicals via HPLC methods.

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