Synthesis of human amyloid restricted to liver results in an Alzheimer’s disease-like neurodegenerative phenotype
- Authors
- Type
- Published Article
- Journal
- PLoS Biology
- Publisher
- Public Library of Science
- Publication Date
- Sep 15, 2021
- Volume
- 19
- Issue
- 9
- Identifiers
- DOI: 10.1371/journal.pbio.3001388
- PMID: 34525093
- PMCID: PMC8443044
- Source
- PubMed Central
- Disciplines
- License
- Unknown
Abstract
Accumulation of amyloid beta (Aβ) in the brain in Alzheimer disease drives pathophysiology. A study in this issue of PLOS Biology revealed that Aβ from the liver can promote brain pathology, supporting that peripheral Aβ can contribute to neurodegeneration.
