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Synthesis of human amyloid restricted to liver results in an Alzheimer’s disease-like neurodegenerative phenotype

Authors
  • Kauwe, Grant
  • Tracy, Tara E.
Type
Published Article
Journal
PLoS Biology
Publisher
Public Library of Science
Publication Date
Sep 15, 2021
Volume
19
Issue
9
Identifiers
DOI: 10.1371/journal.pbio.3001388
PMID: 34525093
PMCID: PMC8443044
Source
PubMed Central
Disciplines
  • Medicine and Health Sciences
  • Gastroenterology and Hepatology
  • Liver Diseases
License
Unknown

Abstract

Accumulation of amyloid beta (Aβ) in the brain in Alzheimer disease drives pathophysiology. A study in this issue of PLOS Biology revealed that Aβ from the liver can promote brain pathology, supporting that peripheral Aβ can contribute to neurodegeneration.

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