Affordable Access

deepdyve-link
Publisher Website

Synthesis of fluorinated building blocks by transition-metal-mediated hydrodefluorination reactions.

Authors
  • Kuehnel, Moritz F
  • Lentz, Dieter
  • Braun, Thomas
Type
Published Article
Journal
Angewandte Chemie International Edition in English
Publisher
Wiley (John Wiley & Sons)
Publication Date
Mar 18, 2013
Volume
52
Issue
12
Pages
3328–3348
Identifiers
DOI: 10.1002/anie.201205260
PMID: 23355490
Source
Medline
License
Unknown

Abstract

The activation and functionalization of carbon-fluorine bonds can be considered as a major challenge in organometallic chemistry. The growing demand for means to introduce fluorine into new materials or into biologically active molecules has inspired the development of diverse synthetic strategies. Hydrodefluorination is regarded as a promising approach to access partially fluorinated building blocks from readily available perfluorinated bulk chemicals. We provide an overview of transition-metal-based complexes and catalysts that were developed to mediate hydrodefluorination reactions. Special emphasis will be placed on discussing the underlying mechanistic patterns and their impact on scope and selectivity. In addition, future requirements for further developing this field will be highlighted.

Report this publication

Statistics

Seen <100 times