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Synthesis and Fluorescent Properties of Biodegradable Hyperbranched Poly(amido amine)s.

Authors
  • Yang, Wen
  • Pan, Cai-Yuan
Type
Published Article
Journal
Macromolecular rapid communications
Publication Date
Dec 16, 2009
Volume
30
Issue
24
Pages
2096–2101
Identifiers
DOI: 10.1002/marc.200900482
PMID: 21638500
Source
Medline
License
Unknown

Abstract

Disulfide-functionalized hyperbranched poly(amido amine)s (HPAMAMs) were synthesized by Michael addition polymerization of N,N'-cystaminebisacrylamide and 1-(2-aminoethyl)piperazine. The novel HPAMAMs displayed bright fluorescence, and the emissions bands cover nearly the whole visible wavelength range. When polymer solutions were excited at 330-385, 460-490, and 510-550 nm, blue, green, and red solutions were observed, respectively. The HPAMAMs are biodegradable and they can be easily cleaved by 2-mercaptoethanol or glutathione, leading to a decrease in the fluorescence intensity. Studies of applications of the biocompatible and biodegradable HPAMAMs in fluorescence imaging technology and biological science are in progress.

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