Synthesis, DNA-damaging and cytotoxic properties of novel topoisomerase II-directed bisantrene analogues.
- Authors
- Type
- Published Article
- Journal
- Bioorganic & Medicinal Chemistry Letters
- Publisher
- Elsevier
- Publication Date
- Jan 20, 1998
- Volume
- 8
- Issue
- 2
- Pages
- 121–126
- Identifiers
- PMID: 9871638
- Source
- Medline
- License
- Unknown
Abstract
New bisantrene analogues were synthesized, bearing one or two 4,5-dihydro-1H-imidazol-2-yl hydrazone side chains at positions 1,4 or 9 of the anthracene ring system. A 10-azabioisostere was also prepared. The position of substituents in structurally isomeric drugs modulates topoisomerase II poisoning and specificity, along with cytotoxicity.
