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Synthesis of cyclic guanidines via Pd-catalyzed alkene carboamination.

Authors
  • Zavesky, Blane P
  • Babij, Nicholas R
  • Fritz, Jonathan A
  • Wolfe, John P
Type
Published Article
Journal
Organic Letters
Publisher
American Chemical Society
Publication Date
Nov 01, 2013
Volume
15
Issue
21
Pages
5420–5423
Identifiers
DOI: 10.1021/ol402377y
PMID: 24147839
Source
Medline
License
Unknown

Abstract

A new approach to the synthesis of substituted 5-membered cyclic guanidines is described. Palladium-catalyzed alkene carboamination reactions between acyclic N-allyl guanidines and aryl or alkenyl halides provide these products in good yield. This method allows access to a number of different cyclic guanidine derivatives in only two steps from readily available allylic amines.

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