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Synthesis of coumarin derivatives with cytotoxic, antibacterial and antifungal activity.

Authors
  • Khan, Khalid Mohammed
  • Saify, Zafar S
  • Khan, Muhammad Zarrar
  • Choudhary, Iqbal M
  • Perveen, Shahnaz
  • Chohan, Zahid H
  • Supuran, Claudiu T
Type
Published Article
Journal
Journal of enzyme inhibition and medicinal chemistry
Publication Date
Aug 01, 2004
Volume
19
Issue
4
Pages
373–379
Identifiers
PMID: 15558956
Source
Medline
License
Unknown

Abstract

The synthesis and selective biological screening of 7-hydroxy-4-methyl-2H-chromen-2-one (2), 7-hydroxy-4,5-dimethyl-2H-chromen-2-one (15) and some of their derivatives were carried out. Compound 13 was found to be most potent cytotoxic agent with LD50 = 126.69 microg/ml. In antibacterial assay the compounds showed a broad spectrum of activities. Compound 11 exhibited a very high degree of plant growth inhibition at three levels of concentration. Compound 4 showed very promising antifungal activity against Candida albicans. Compounds 12 and 13 demonstrated excellent antioxidant activity.

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