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A synthesis of cost-utility analysis literature in infectious disease.

Authors
  • Stone, Patricia W
  • Schackman, Bruce R
  • Neukermans, Christopher P
  • Olchanski, Natalia
  • Greenberg, Dan
  • Rosen, Allison B
  • Neumann, Peter J
Type
Published Article
Journal
The Lancet Infectious Diseases
Publisher
Elsevier
Publication Date
Jun 01, 2005
Volume
5
Issue
6
Pages
383–391
Identifiers
PMID: 15919624
Source
Medline
License
Unknown

Abstract

The purpose of this review is to understand infectious disease-related cost-utility analyses by describing published analyses, examining growth and quality trends over time, examining factors related to quality, and summarising standardised results. 122 cost-utility analyses and 352 cost-utility ratios were identified. Pharmaceutical interventions were most common (47.5%); three author groups accounted for 42.8% of pharmaceutical ratios. High-volume journals (three or more published cost-utility analyses) published higher quality analyses than low-volume journals (p<0.001). Use of probabilistic sensitivity analysis and discounting at 3% were more frequently found in the years after the US Public Health Service Panel on Cost-Effectiveness in Health and Medicine recommendations (p<0.01). Median ratios varied from US13,500 dollars/quality-adjusted life year (QALY) for immunisations to US810,000 dollars/QALY for blood safety. Publication of infectious disease cost-utility analyses is increasing. The results of cost-utility analyses have important implications for the development of clinical guidelines and resource allocation decisions. More trained investigators and better peer-review processes are needed.

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