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Synthesis and comparative evaluation of two antiviral agents: beta-L-Fd4C and beta-D-Fd4C.

Authors
  • Chen, S H
  • Lin, S
  • King, I
  • Spinka, T
  • Dutschman, G E
  • Gullen, E A
  • Cheng, Y C
  • Doyle, T W
Type
Published Article
Journal
Bioorganic & Medicinal Chemistry Letters
Publisher
Elsevier
Publication Date
Nov 17, 1998
Volume
8
Issue
22
Pages
3245–3250
Identifiers
PMID: 9873711
Source
Medline
License
Unknown

Abstract

The synthesis of beta-D-Fd4C was achieved in a stereoselective fashion from D-xylose. The antiviral activity and cytotoxicity of beta-D-Fd4C was compared with that of beta-L-Fd4C and 3TC (Lamivudine). Of the three agents compared, beta-L-Fd4C was found to be the most potent antiviral agent.

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