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Synthesis and characterization of porous CaCO3 microspheres templated by yeast cells and the application as pH value-sensitive anticancer drug carrier.

Authors
  • Wei, Yan1
  • Sun, Ruize2
  • Su, Hui2
  • Xu, Hao2
  • Zhang, Lichuang2
  • Huang, Di3
  • Liang, Ziwei2
  • Hu, Yinchun2
  • Zhao, Liqin2
  • Lian, Xiaojie2
  • 1 Department of Biomedical Engineering, Research Center for Nano-Biomaterials & Regenerative Medicine, College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan, Shanxi, 030024, China. Electronic address: [email protected] , (China)
  • 2 Department of Biomedical Engineering, Research Center for Nano-Biomaterials & Regenerative Medicine, College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan, Shanxi, 030024, China. , (China)
  • 3 Department of Biomedical Engineering, Research Center for Nano-Biomaterials & Regenerative Medicine, College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan, Shanxi, 030024, China. Electronic address: [email protected] , (China)
Type
Published Article
Journal
Colloids and surfaces. B, Biointerfaces
Publication Date
Dec 26, 2020
Volume
199
Pages
111545–111545
Identifiers
DOI: 10.1016/j.colsurfb.2020.111545
PMID: 33373843
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Using yeast as organic template and PDDA/PSS with opposite charge as polyelectrolyte, CaCO3 was deposited on yeast cells by Layer-by-Layer self-assembly method, and then porous calcium carbonate hybrid microspheres (CaCO3-HMPs) were prepared by calcination. The CaCO3-HMPs were characterized by FT-IR, XRD, SEM and TG. It was found that the prepared CaCO3-HMPs were nearly spherical, with visible pores on the surface, small particle size uniformity (d = 3 μ m) and good dispersion. Doxorubicin hydrochloride (DOX) was used as the model drug to study drug loading and release properties of CaCO3-HMPs. Then, the drug loading, DOX release under different pH conditions, and the degradation of CaCO3-HMPs under different pH conditions were investigated. The drug release test results showed that the DOX-loaded microspheres released more drugs (99 %) at pH = 4.8 than pH = 7. It indicated that the CaCO3-HMPs were pH sensitive. The cytotoxicity of DOX-loaded microspheres was also studied. It was found that CaCO3-HMPs had good biocompatibility. In addition, compared with DOX group, cytotoxicity test results showed that the DOX-loaded microspheres had the same efficacy but sustained drug release for up to 120 h. Therefore, the CaCO3-HMP microspheres have good application prospects as anticancer drug carriers. Copyright © 2020 Elsevier B.V. All rights reserved.

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