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Synthesis, Characterization and Biological Activities of a Bidentate Schiff Base Ligand: N,N '-Bis(1-phenylethylidene)ethane-1,2-diamine and its Transition Metals (II) Complexes

Authors
  • Parvez, Shoukat
  • Anis, Itrat
  • Afza, Nighat
  • Aslam, Muhammad
  • Hussain, Muhammad Tahir
  • Hussain, Ajaz
  • Sherazi, Tauqir Ali
  • Shah, Muhammad Raza
  • Khalid, Muhammad
  • Bokhari, Tanveer Hussain
Publication Date
Jan 01, 2012
Source
Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (BDPI USP)
Keywords
Language
English
License
Unknown
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Abstract

Schiff base ligand: N,N'-bis(1-phenylethylidene)ethane-1,2-diamine (L), was derived from acetophenone and ethylenediamine by condensation and its complexes (1-5) were prepared with Pb2+, Ni2+, Co2+, Cu2+ and Cd2+ metal ions. Their structures were characterized by FAB-MS, IR spectra, elemental analyses and molar conductance. The octahedral geometry of the complexes was proposed by electronic spectra and magnetic moment data. The conductivity data showed that the complexes have non-electrolytic nature. The complexes (1-5) have higher in vitro antimicrobial activity than the Schiff base ligand (L). In the nuclease activity, the complexes cleave DNA as compared to control DNA in the presence of H2O2.

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