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Synthesis and characterisation of new copolymers for medical imaging visualization of medical device.

Authors
  • Younis, Mira
Publication Date
Dec 17, 2015
Source
HAL-UPMC
Keywords
Language
English
License
Unknown
External links

Abstract

Synthetic polymers are widely used nowadays as prosthetic implants. Unfortunately, these implants are invsisble by magnetic resonance imaging (MRI). The visualization of these implants is a necessity in order to gain information concerning their fixation in the body and post-operation fate. One of the challenges is then to fix a contrast agent on the implant. Thus the objective is to develop novel strategies for the long-term visualization of prosthetic implants by MRI. For this goal, a polymer will first be functionalized with a contrast agent in a covalent way, and then it will be deposited by coating on the surface of the prosthesis. Polymers will be functionalized by free radical polymerization followed by “click chemistry. In a first step, poly(methyl methacrylate-co-propargyl methacrylate) with low molar ratio in propargyl methacrylate (F< 10 %) will be prepared by free radical copolymerization of methyl methacrylate with propargyl methacrylate. In a second step, a novel gadolinium based contrast agent will be grafted by click chemistry onto the propargylated poly(methyl methacrylate) (PMMA-co-PMA) polymer. The obtained polymeric contrast agent will be spread on a commercial polypropylene mesh by the airbrushing technique and the mesh will be assessed for MRI visualization on a 7T instrument. Cytocompatibility and cytotoxicity tests will be performed to evaluate the use of this contrast agent in biomedical applications.At the same time, fluorescence imaging techniques are also gaining popularity. For this, the same synthesized polymer (PMMA-co-PMA) will be attached to different fluorescent precursors: anthracene, fluoresceine, and europium complex.

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