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Synthesis and biological properties of the seven alanine-modified analogues of the marine cyclopeptide hymenamide C.

Authors
  • Napolitano, Assunta
  • Bruno, Ines
  • Rovero, Paolo
  • Lucas, Rut
  • Peris, Miguel Payà
  • Gomez-Paloma, Luigi
  • Riccio, Raffaele
Type
Published Article
Journal
Journal of peptide science : an official publication of the European Peptide Society
Publication Date
Aug 01, 2002
Volume
8
Issue
8
Pages
407–417
Identifiers
PMID: 12212804
Source
Medline
License
Unknown

Abstract

The synthesis and biological activity of the marine cyclopeptide hymenamide C(1), showing an inhibitory effect on human neutrophil elastase degranulation release, were recently described. Based on this result, it was decided to undertake a systematic structure-activity relationship study of this cyclopeptide, based on the Ala-scan technique, in order to obtain useful information for the rational design of additional analogues. The synthesis and characterization of the seven Ala modified analogues are reported and their biological and pharmacological properties are described.

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