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Synthesis and biological evaluation of novel 4"-alkoxy avermectin derivatives.

Authors
  • Nagai, Kenichiro
  • Shiomi, Kazuro
  • Sunazuka, Toshiaki
  • Harder, Achim
  • Turberg, Andreas
  • Omura, Satoshi
Type
Published Article
Journal
Bioorganic & Medicinal Chemistry Letters
Publisher
Elsevier
Publication Date
Aug 16, 2004
Volume
14
Issue
16
Pages
4135–4139
Identifiers
PMID: 15261257
Source
Medline
License
Unknown

Abstract

Novel 4"-alkoxy avermectin derivatives were synthesized via rhodium carbenoid mediated O-H insertion reaction and tested for antiparasite activity against Artemia salina and Caenorhabditis elegans.

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