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Synthesis and biological evaluation of 3-arylisoquinolines as antitumor agents.

Authors
  • Cho, W J
  • Park, M J
  • Chung, B H
  • Lee, C O
Type
Published Article
Journal
Bioorganic & Medicinal Chemistry Letters
Publisher
Elsevier
Publication Date
Jan 06, 1998
Volume
8
Issue
1
Pages
41–46
Identifiers
PMID: 9871625
Source
Medline
License
Unknown

Abstract

To investigate the structure-activity relationship of 7,8-dimethoxy-2- methyl-3-(4,5-methylenedioxy-2-vinylphenyl)isoquinolin-1(2H) -one 2, diverse substituted 3-arylisoquinolines were synthesized and tested in vitro antitumor activity against five human tumor cell lines. The results showed a broad antitumor spectrum for a series of 3-arylisoquinolines.

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