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Synthesis and biological activities of 2-functionalized purine nucleosides.

Authors
  • Nair, Vasu
  • Bera, Bindu
  • Kern, Earl R
Type
Published Article
Journal
Nucleosides, nucleotides & nucleic acids
Publication Date
Feb 01, 2003
Volume
22
Issue
2
Pages
115–127
Identifiers
PMID: 12744599
Source
Medline
License
Unknown

Abstract

Novel purine nucleosides functionalized at the 2-position have been prepared using new applications of synthetic methodology. The target molecules were designed as potential inhibitors (as their monophosphates) of the enzyme, inosine monophosphate dehydrogenase (IMPDH), and representative inhibition data are presented. Antiviral data of the compounds are discussed.

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