Synthesis and bioactivity of psilocybin analogues containing a stable carbon-phosphorus bond
- Authors
- Publication Date
- Jan 01, 2024
- Source
- Ghent University Institutional Archive
- Keywords
- Language
- English
- License
- Green
- External links
Abstract
Psilocybin analogues have been synthesized comprising a non-hydrolysable P-C bond to evaluate the biological activity and the selectivity towards 5-HT2AR, 5-HT2BR and the TNAP receptor. No activity was observed towards the phosphatase, however all compounds showed good binding affinity for 5-HT2AR and 5-HT2BR and one compound showed a higher selectivity towards 5-HT2AR than psilocin. Psilocybin analogues have been synthesized comprising a non-hydrolysable P-C bond to evaluate the biological activity and the selectivity towards 5-HT2AR, 5-HT2BR and the TNAP receptor.
