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Synthesis of betaglycan-type tetraosyl hexapeptide: a possible precursor regulating enzymatic elongation toward heparin.

Authors
  • Tamura, Jun-ichi
  • Yamaguchi, Akihiro
  • Tanaka, Junko
Type
Published Article
Journal
Bioorganic & Medicinal Chemistry Letters
Publisher
Elsevier
Publication Date
Aug 05, 2002
Volume
12
Issue
15
Pages
1901–1903
Identifiers
PMID: 12113804
Source
Medline
License
Unknown

Abstract

TETRAOSYL HEXAPEPTIDE, A PART OF THE SEQUENCE OF BETAGLYCAN: beta-D-GlcA-(1-->3)-beta-D-Gal-(1-->3)-beta-D-Gal-(1-->4)-beta-D-Xyl-(1-->O-SerGlyTrpProAspGly (1), which was designed as a probe for glycan elongation toward heparin, was synthesized in a stereocontrolled manner.

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