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Synthesis of aromatic lactone analogues of Lipoxin A4

Authors
  • Ismael, Aya1
  • Zeeshan, Muhammad1
  • Hansen, Jørn H.1
  • 1 UiT The Arctic University of Norway, Tromsø, 9037, Norway , Tromsø (Norway)
Type
Published Article
Journal
BMC Research Notes
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Feb 09, 2022
Volume
15
Issue
1
Identifiers
DOI: 10.1186/s13104-022-05917-4
Source
Springer Nature
Keywords
Disciplines
  • Research Note
License
Green

Abstract

ObjectiveSynthesis of novel aromatic Lipoxin A4 lactone analogues.ResultsNovel para-substituted aromatic lactone analogues of Lipoxin A4 have been synthesized in a convergent manner with six steps in the longest linear sequence in 12–13% yields, employing 2-deoxy-d-ribose as a chiral pool starting material and the classical E-selective Wittig olefination.

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