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Synthesis and antiulcer activity evaluation of conjugates of amino acids with N-aroyl- N, N'-dicyclohexyl urea.

Authors
  • Subudhi, Bharat Bhusan
  • Sahoo, Shakti Prasanna
Type
Published Article
Journal
Chemistry Central journal
Publication Date
Jan 01, 2011
Volume
5
Pages
86–86
Identifiers
DOI: 10.1186/1752-153X-5-86
PMID: 22185518
Source
Medline
License
Unknown

Abstract

Amino acids are safe molecules with variable efficacy against ulceration. Considering the good antioxidant potential of N-aroyl- N, N'-dicyclohexyl urea and antiulcer activities of amino acids, a series of amino acid conjugates of N-aroyl- N, N'-dicyclohexyl urea was synthesized and the effect against ulceration in albino rats induced by pyloric ligation was screened. All these compounds were found to be safe and active. Reduction of ulcer index was significant for all compounds. Conjugates of methionine and histidine exhibited enhanced antiulcer activity comparable to omeprazole in terms of inhibition of release of gastric juice, hydrochloric acid and neutralization activity. The promising efficacy and safety of these compounds is interesting for further investigation.

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