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Synthesis and antiproliferative activity of 2-triazenothiophenes.

Authors
  • Diana, P
  • Barraja, P
  • Lauria, A
  • Almerico, A M
  • Cirrincione, G
  • Minnei, C
  • Longu, S
  • Congiu, D
  • Musiu, C
  • La Colla, P
Type
Published Article
Journal
Anticancer research
Publication Date
Jan 01, 1999
Volume
19
Issue
3A
Pages
2127–2131
Identifiers
PMID: 10470160
Source
Medline
License
Unknown

Abstract

A series of 2-triazenothiophene derivatives was prepared and tested to evaluate their biological activity. Two compounds inhibited the proliferation of leukemia, lymphoma and solid tumor-derived cell lines at micromolar concentrations, whereas none of the compounds were active against HIV-1. Compound 3c inhibited DNA, RNA and protein synthesis, and was also effective against KB cells resistant to etoposide and vincristine. The compounds were inactive against fungi and bacteria.

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