Affordable Access

deepdyve-link
Publisher Website

Synthesis, antimicrobial potency with in silico study of Boc-leucine-1,2,3-triazoles.

Authors
  • Naveen,1
  • Tittal, Ram Kumar2
  • Ghule, Vikas D1
  • Yadav, Pinki3
  • Lal, Kashmiri4
  • Kumar, Ashwani5
  • 1 Department of Chemistry, National Institute of Technology Kurukshetra, Haryana 136119, India. , (India)
  • 2 Department of Chemistry, National Institute of Technology Kurukshetra, Haryana 136119, India. Electronic address: [email protected] , (India)
  • 3 Department of Chemistry, Guru Jambheshwar University of Science & Technology (GJUS&T), Hisar, Haryana 12500, India. , (India)
  • 4 Department of Chemistry, Guru Jambheshwar University of Science & Technology (GJUS&T), Hisar, Haryana 12500, India. Electronic address: [email protected] , (India)
  • 5 Department of Pharmaceutical Sciences, GJUS&T, Hisar, Haryana 12500, India. , (India)
Type
Published Article
Journal
Steroids
Publication Date
Sep 01, 2020
Volume
161
Pages
108675–108675
Identifiers
DOI: 10.1016/j.steroids.2020.108675
PMID: 32531313
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

A library of N-Boc protected Leucine-linked 1,4-disubstituted 1,2,3-triazoles was synthesized and fully characterized, in high yield via copper-catalyzed alkyne-azide cycloaddition (CuAAC) reaction. In vitro antibacterial activity showed that compound 4h found to be more potent than the reference drug Ciprofloxacin (MIC: 0.0196 µmol/mL) against tested bacterial strains S. entrica, B. subtilis, S. aureus, E. coli and P. auroginosa with MIC: 0.0148, 0.0074, 0.0148, 0.0074, and 0.0074 µmol/mL, respectively and antifungal activity with MIC: 0.0148 µmol/mL as compared to reference drug Fluconazole (MIC: 0.0102 µmol/mL) against A. niger and C. albicans fungal strains. Further, the molecular docking study on 4h and its predecessor alkyne 3 by choosing E. coli topoisomerase II, DNA Gyrase (PDB ID: 1KZN) showed better binding with triazole than alkyne and these results were supported by DFT study using B3LYP/6-311G(d,p) basis set. Copyright © 2020 Elsevier Inc. All rights reserved.

Report this publication

Statistics

Seen <100 times